Author: Michael

Eisai and Biogen presented data at the Alzheimer’s Association International Conference 2026 in London showing that a lecanemab subcutaneous autoinjector (LEQEMBI) produced exposure, efficacy and safety comparable to the approved intravenous initiation regimen in people with early Alzheimer’s disease. According to the company, once-weekly 500 mg subcutaneous administration demonstrated bioequivalence to the IV initiation regimen (10 mg/kg every two weeks) with an exposure ratio of 104% (90% confidence interval 99.1%–109%) and consistent exposure across body weight quartiles. The companies claim that amyloid reduction measured by PET, clinical efficacy on CDR-SB and incidence of ARIA-E were driven by lecanemab exposure rather…

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