Insilico Medicine, a clinical-stage biotechnology

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Hopeful mouse data suggest restoring the brain’s energy balance could do what decades of research have not: push Alzheimer’s into retreat. For more than a century, treatments for Alzheimer’s disease have largely focused on slowing decline, not turning it around. But a new study from University Hospitals Cleveland Medical Center is quietly challenging that assumption, offering a different way of thinking about the disease. Now, it’s seen not just as toxic buildup in the brain, but as a crisis of energy. In experiments involving mice and human brain tissue, researchers found that restoring balance to a molecule essential for cellular energy dramatically reversed Alzheimer’s-like damage [1]. The findings, published last week in Cell Reports Medicine, do not claim a cure. But they do reopen a door many thought was permanently closed. The center of the study is NAD+, a molecule found in every cell of the body. It helps cells turn nutrients into usable energy and repair everyday damage. NAD+ is especially important in organs that work nonstop, including the brain. Researchers examined two mouse models of Alzheimer’s alongside human Alzheimer’s brain tissue and found the same pattern: severe depletion of NAD+ [1]. “NAD+ naturally declines with age. When NAD+…

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